1-Cbz-4-Piperidinecarboxylic Acid
1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid
CAS: 10314-98-4
Molecular Formula: C14H17NO4
1-Cbz-4-Piperidinecarboxylic Acid - Names and Identifiers
1-Cbz-4-Piperidinecarboxylic Acid - Physico-chemical Properties
| Molecular Formula | C14H17NO4 |
| Molar Mass | 263.29 |
| Density | 1.265±0.06 g/cm3(Predicted) |
| Melting Point | 78 °C |
| Boling Point | 443.9±45.0 °C(Predicted) |
| Flash Point | 222.3°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 1.16E-08mmHg at 25°C |
| Appearance | Solid |
| Color | White to Almost white |
| pKa | 4.55±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD01568759 |
1-Cbz-4-Piperidinecarboxylic Acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S37/39 - Wear suitable gloves and eye/face protection |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
1-Cbz-4-Piperidinecarboxylic Acid - Introduction
N-Cbz-Piperidine-4-carboxylic acid is an organic compound with the chemical formula of C, H, N, O. The following is a description of the properties, uses, preparation and safety information of N-Cbz-piperidine-4-carboxylic acid:
Nature:
N-Cbz piperidine-4-carboxylic acid is a white crystalline solid. It is relatively stable at room temperature, but may degrade under high temperature or light. It has low solubility and can be dissolved in some organic solvents, such as dimethylformamide (DMF) or dichloromethane.
Use:
N-Cbz-piperidine-4-carboxylic acid is often used as a protecting group or intermediate in organic synthesis. It can react with amines or alcohols to form temporary protecting groups to prevent side reactions of other functional groups in the reaction. In addition, it can also be used as a key intermediate for the preparation of drug molecules, such as piperidines and N-Cbz-amino acids.
Preparation Method:
N-Cbz-piperidine-4-carboxylic acid is usually synthesized by a two-step reaction. First, piperidine is reacted with benzoyl chloride to form the N-Cbz-piperidine compound. This compound then undergoes an acid hydrolysis reaction to yield the final product, N-Cbz-piperidine-4-carboxylic acid. This synthesis process requires some organic solvents and acid catalysts.
Safety Information:
N-Cbz-piperidine-4-carboxylic acid is generally relatively safe under normal conditions of use, but the following safety precautions still need to be paid attention:
-Contact with skin, eyes or use may cause danger, please avoid direct contact. Wear appropriate protective equipment such as gloves, goggles and lab coats when working.
-When using, pay attention to avoid inhaling the dust or steam of the substance. The operation should be carried out in a well-ventilated laboratory environment.
-When storing, keep it in a dry, cool place, and away from fire and oxidizing agents.
Nature:
N-Cbz piperidine-4-carboxylic acid is a white crystalline solid. It is relatively stable at room temperature, but may degrade under high temperature or light. It has low solubility and can be dissolved in some organic solvents, such as dimethylformamide (DMF) or dichloromethane.
Use:
N-Cbz-piperidine-4-carboxylic acid is often used as a protecting group or intermediate in organic synthesis. It can react with amines or alcohols to form temporary protecting groups to prevent side reactions of other functional groups in the reaction. In addition, it can also be used as a key intermediate for the preparation of drug molecules, such as piperidines and N-Cbz-amino acids.
Preparation Method:
N-Cbz-piperidine-4-carboxylic acid is usually synthesized by a two-step reaction. First, piperidine is reacted with benzoyl chloride to form the N-Cbz-piperidine compound. This compound then undergoes an acid hydrolysis reaction to yield the final product, N-Cbz-piperidine-4-carboxylic acid. This synthesis process requires some organic solvents and acid catalysts.
Safety Information:
N-Cbz-piperidine-4-carboxylic acid is generally relatively safe under normal conditions of use, but the following safety precautions still need to be paid attention:
-Contact with skin, eyes or use may cause danger, please avoid direct contact. Wear appropriate protective equipment such as gloves, goggles and lab coats when working.
-When using, pay attention to avoid inhaling the dust or steam of the substance. The operation should be carried out in a well-ventilated laboratory environment.
-When storing, keep it in a dry, cool place, and away from fire and oxidizing agents.
Last Update：2024-04-09 21:01:54
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